Cells activate AMPK when they are running low on energy, and AMPK is activated in tissues throughout the body following exercise or during calorie restriction. "It really gives us a new way to define the health benefits of this specific enzyme in a wide variety of diseases."ĪMP-activated protein kinase, or AMPK, is known as a master regulator of metabolism. "This model will allow us to answer questions that scientists could not answer before," says Salk Professor and Salk Cancer Center Director Reuben Shaw, who led the new work. In the paper, published Januin the journal Cell Reports, the Salk team uses the new model to activate AMPK in the livers of adult mice with fatty liver disease. Now, Salk researchers have developed a new system that lets them study in more detail than ever exactly how, where and when AMPK carries out its molecular and therapeutic functions.
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